Nanocarriers are transport systems that are capable of transporting and delivering active ingredients in a targeted manner. They are used in medicine and pharmacy to improve the bioavailability of therapeutic agents and enable their targeted delivery to specific locations in the body.
InnoMedica relies on the use of liposomes, artificially produced vesicle structures that consist of a lipid bilayer and are modeled on the body's own natural transport systems. These liposomal nanocarriers are loaded with an active ingredient and can be targeted to the site of the disease, which is intended to protect healthy tissue. The longer retention time of the active ingredient in the bloodstream and the targeted distribution of the drug in the body not only reduce side effects but also improve efficacy. There are almost no limits to the variety of applications in the loading of InnoMedica's liposomal nanocarriers.
InnoMedica's current focus in the application of liposomal nanocarriers is in the fields of oncology, with the development of a gentler chemotherapy, and neurology, with a drug against neurodegenerative diseases.
The nanocarrier of InnoMedica's oncology product transports the already approved, highly effective active ingredient doxorubicin and is designed to prevent serious, sometimes irreversible side effects of this chemotherapy. The intelligent surface coating of the liposomal nanoparticle ensures minimal interaction of the active ingredient with healthy tissue. The longer blood circulation time protects the excretory organs as they have more time for the degradation process. As the liposomal nanocarrier of the preparation is particularly small, targeted penetration of the tumor tissue is ensured, and thus, a high level of drug accumulation in the tumor is ensured.
Thanks to the unique composition of the nanocarrier for InnoMedica's neurology product, the active ingredient GM1 ganglioside that is integrated into the membrane can cross the blood-brain barrier and unfold its neuroprotective and neuroregenerative effect in the brain. GM1 ganglioside is an important component of nerve cells and plays a central role in neuronal development, information transmission and storage, in repair mechanisms and in the release of neurotrophins (messenger substances that are essential for the survival and regeneration of nerve cells). As InnoMedica's nanocarrier crosses the blood-brain barrier, the brain is supplied with more GM1 to protect the nerve cells. As it is an endogenous substance, it is also well tolerated.
